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According to South Park's website, the new episode for Wednesday will tackle Fake Writer James Frey's historic appearance on Oprah:

Towelie gets over his drug addition and writes a moving book about his experiences. Thanks to Oprah's support, the book becomes a best seller and his story inspires millions to turn their lives around. However, when he's caught in a lie by the grand dame of daytime television, Towelie's old habits start to look might appealing.

Obviously, Frey will be played by Towelie, and a self-righteous cartoon will portray Oprah with the two-dimensional justice she deserves.

South Park Studios
Earlier: James Frey on Oprah: Liveblogging the Live Feed